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I depends what type. Some have spermacides which will kill the sperm. Even ones that don't will likely damage the sperm. Are you in your fertile period? I find we don't need anything in the most fertile days as I have plenty of cm then. We use preseed at other times because it is the nicest feeling lubricant!

yes, im in my fertile period. I thought I had lots of cm. Felt like it to me. but bf said it hurt a little to go in, so we used a bit of lube.